PUBLICATIONS論文
- Yoshihiro T, Yamaguchi K, Ariyama H, Koreishi S, Uehara K, Ohmura H, Ito M, Tsuchihashi K, Isobe T, Shindo K, Ohuchida K, Nakamura M, Nagao Y, Oda Y, Akashi K, Baba E.
Elucidation of the mechanism of carcinogenic transformation of human gastric epithelial cells in atrophic gastritis.
Biochimica et Biophysica Acta – Molecular Basis of Disease. 2025;1871(6):167843. https://pubmed.ncbi.nlm.nih.gov/40220876/
- Tanoue K, Ohmura H, Uehara K, Ito M, Kusaba H, Kimura Y, Shimose T, Ando K, Hashiguchi T, Kuwano H, Maehara Y, Baba E.
Spatial dynamics of CD39+ CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer.
Nature Communications. 2024;15:9033.
https://pubmed.ncbi.nlm.nih.gov/39426955/
- JCOG1109 NExT Study Group.
Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial.
The Lancet. 2024;404(10447):55–66.
https://pubmed.ncbi.nlm.nih.gov/38876133/
- Yamaguchi K, Ito M, Isobe T, Koreishi S, Taguchi R, Uehara K, Ueno S, Imajima T, Kitazono T, Tsuchihashi K, Ohmura H, Yoshihiro T, Tanoue K, Nishiyori S, Iwama E, Maeda T, Akashi K, Baba E.
Impact of Genomic Alterations on Efficacy of Trastuzumab Deruxtecan Against Human Epidermal Growth Factor Receptor-2-Positive Advanced Gastric Cancer.
JCO Precision Oncology. 2024;8: e2300681.
https://pubmed.ncbi.nlm.nih.gov/38748981/
- Shimoi T, Sunami K, Tahara M, Nishiwaki S, Tanaka S, Baba E, Ozaka M, Ando M, Kato K, Yamada Y, Yoshino T, Esaki T, Makiyama A, Doi T, Sakai D.
Dabrafenib and trametinib administration in patients with BRAF V600E/R or non-V600 BRAF mutated advanced solid tumours (BELIEVE, NCCH1901): a multicentre, open-label, and single-arm phase II trial.
EClinicalMedicine. 2024;69:102447.
https://pubmed.ncbi.nlm.nih.gov/38333370/
- Abutani H, Ito M, Oda Y, Yoshizumi T, Nakamura M, Baba E.
Homologous recombination repair gene alterations are a biomarker predicting tumor mutational burden-high and good response to immunotherapy.
Targeted Oncology. 2024;19(1):41–51.
https://pubmed.ncbi.nlm.nih.gov/38067312/
- Uehara K, Tanoue K, Yamaguchi K, Ohmura H, Ito M, Matsushita Y, Tsuchihashi K, Tamura S, Shimokawa H, Isobe T, Shibata Y, Ariyama H, Tanaka R, Kusaba H, Yamamoto H, Oda Y, Akashi K, Baba E.
Preferential B cell differentiation by combined immune checkpoint blockade for renal cell carcinoma is associated with clinical response and autoimmune reactions.
Cancer Immunology, Immunotherapy. 2023;72(11):2853–2865. https://pubmed.ncbi.nlm.nih.gov/37550428/
- Nakano M, Taguchi R, Kikushige Y, Isobe T, Miyawaki K, Mizuno S, Tsuruta N, Hanamura F, Yamaguchi K, Yamauchi T, Ariyama H, Kusaba H, Nakamura M, Maeda T, Kuo CJ, Baba E, Akashi K.
RHAMM marks proliferative subpopulation of human colorectal cancer stem cells.
Cancer Science. 2023;114(7):2895–2906.
https://pubmed.ncbi.nlm.nih.gov/36945114/
- Yoshihiro T, Ariyama H, Yamaguchi K, Imajima T, Yamaga S, Tsuchihashi K, Isobe T, Kusaba H, Akashi K, Baba E.
Inhibition of insulin-like growth factor-1 receptor enhances eribulin-induced DNA damage in colorectal cancer.
Cancer Science. 2022;113(12):4207–4218.
https://pubmed.ncbi.nlm.nih.gov/36053154/
- Yamaguchi K, Yoshihiro T, Ariyama H, Ito M, Nakano M, Semba Y, Nogami J, Tsuchihashi K, Yamauchi T, Ueno S, Isobe T, Shindo K, Moriyama T, Ohuchida K, Nakamura M, Nagao Y, Ikeda T, Hashizume M, Konomi H, Torisu T, Kitazono T, Kanayama T, Tomita H, Oda Y, Kusaba H, Maeda T, Akashi K, Baba E.
Potential therapeutic targets discovery by transcriptome analysis of an in vitro human gastric signet ring carcinoma model.
Gastric Cancer. 2022;25(5):862–878.
https://pubmed.ncbi.nlm.nih.gov/35661943/
- Ito M, Nakano M, Ariyama H, Yamaguchi K, Tanaka R, Semba Y, Sugio T, Miyawaki K, Kikushige Y, Mizuno S, Isobe T, Tanoue K, Taguchi R, Ueno S, Kawano T, Murata M, Baba E, Akashi K.
Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions.
Cancer Letters. 2022;532:215597.
https://pubmed.ncbi.nlm.nih.gov/35150810/
- Tanoue K, Tamura S, Kusaba H, Shinohara Y, Ito M, Tsuchihashi K, Shirakawa T, Otsuka T, Ohmura H, Isobe T, Ariyama H, Koreishi S, Matsushita Y, Shimokawa H, Tanaka R, Mitsugi K, Akashi K, Baba E.
Predictive impact of C-reactive protein to albumin ratio for recurrent or metastatic head and neck squamous cell carcinoma receiving nivolumab.
Scientific Reports. 2021;11(1):2741.
https://pubmed.ncbi.nlm.nih.gov/33531609/
- Tsuchihashi K, Kusaba H, Yoshihiro T, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Imajima T, Shinohara Y, Ito M, Yamaga S, Tanoue K, Arimizu K, Ohmura H, Hanamura F, Yamaguchi K, Isobe T, Ariyama H, Nakashima Y, Akashi K, Baba E.
Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin.
Scientific Reports. 2020;10(1):20896.
https://pubmed.ncbi.nlm.nih.gov/33262403/
- Ohmura H, Yamaguchi K, Hanamura F, Ito M, Makiyama A, Uchino K, Shimokawa H, Tamura S, Esaki T, Mitsugi K, Shibata Y, Oda H, Tsuchihashi K, Ariyama H, Kusaba H, Oda Y, Akashi K, Baba E.
OX40 and LAG3 are associated with better prognosis in advanced gastric cancer patients treated with anti-programmed death-1 antibody.
British Journal of Cancer. 2020;122(10):1507–1517.
https://pubmed.ncbi.nlm.nih.gov/32203221/
- Yamaguchi K, Ito M, Ohmura H, Hanamura F, Nakano M, Tsuchihashi K, Nagai S, Ariyama H, Kusaba H, Yamamoto H, Oda Y, Nakamura M, Akashi K, Baba E.
Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancer.
OncoImmunology. 2020;9(1):1724763.
https://pubmed.ncbi.nlm.nih.gov/32117589/
- Takayoshi K, Kusaba H, Aikawa T, Koreishi S, Sagara K, Nakano M, Komoda M, Kono M, Fukata M, Arita T, Esaki T, Akashi K, Baba E.
Hypoalbuminemia for the prediction of venous thromboembolism and treatment of direct oral anticoagulants in metastatic gastric cancer patients.
Gastric Cancer. 2019;22(5):988–998.
https://pubmed.ncbi.nlm.nih.gov/30788749/
- Yamaguchi K, Nakano M, Ito M, Koreishi S, Oda Y, Tachimori A, Ariyama H, Kusaba H, Baba E.
PD-1⁺ TIM-3⁺ T cells in malignant ascites predict prognosis of gastrointestinal cancer.
Cancer Science. 2018;109(10):2985–2993.
https://pubmed.ncbi.nlm.nih.gov/30187676/
- Nakano M, Kikushige Y, Miyawaki K, Kunisaki Y, Mizuno S, Takenaka K, Tamura S, Okumura Y, Ito M, Ariyama H, Kusaba H, Nakamura M, Maeda T, Baba E, Akashi K.
Dedifferentiation process driven by TGF-beta signaling enhances stem cell properties in human colorectal cancer.
Oncogene. 2019;38(6):780–793.
https://pubmed.ncbi.nlm.nih.gov/30181548/
- Nakano M, Ito M, Tanaka R, Ariyama H, Kawamura H, Kusaba H, Oda Y, Tachimori A, Baba E.
Epithelial-mesenchymal transition is activated in CD44-positive malignant ascites tumor cells of gastrointestinal cancer.
Cancer Science. 2018;109(11):3461–3470.
https://pubmed.ncbi.nlm.nih.gov/30142697/
- Yamaguchi K, Kusaba H, Ito M, Koreishi S, Ariyama H, Baba E.
Activation of central/effector memory T cells and T-helper 1 polarization in malignant melanoma patients treated with anti-programmed death-1 antibody.
Cancer Science. 2018;109(10):3032–3042.
https://pubmed.ncbi.nlm.nih.gov/30066977/
- Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, Akashi K, Baba E.
E-cadherin regulates proliferation of colorectal cancer stem cells through NANOG.
Oncology Reports. 2018;40(2):693–703.
https://pubmed.ncbi.nlm.nih.gov/29845283/
- Makiyama A, Kunieda K, Noguchi M, Kajiwara T, Tamura T, Takeda K, Sugiyama J, Minashi K, Moriwaki T, Sugimoto N, Nagase M, Negoro Y, Tsuda T, Shimodaira H, Okano N, Tsuji A, Sakai D, Yanagihara K, Ueda S, Tamura S, Otsu S, Honda T, Matsushita Y, Okuno T, Kashiwada T, Nozaki A, Ebi M, Okuda H, Shimokawa M, Hironaka S, Hyodo I, Baba E, Boku N, Muro K, Esaki T.
First-line chemotherapy with S-1 alone or S-1 plus cisplatin for elderly patients with advanced gastric cancer: a multicenter propensity score matched study.
Gastric Cancer. 2018;21(5):792–801.
https://pubmed.ncbi.nlm.nih.gov/29353332/
- Makiyama A, Arimizu K, Hirano G, Makiyama C, Matsushita Y, Shirakawa T, Ohmura H, Komoda M, Uchino K, Inadomi K, Arita S, Ariyama H, Kusaba H, Shinohara Y, Kuwayama M, Kajitani T, Oda H, Esaki T, Akashi K, Baba E.
Irinotecan monotherapy as third-line or later treatment in advanced gastric cancer.
Gastric Cancer. 2018;21(3):464–472.
https://pubmed.ncbi.nlm.nih.gov/28799048/
- Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, Humblet Y, Bouché O, Mineur L, Barone C, Adenis A, Tabernero J, Yoshino T, Lenz HJ, Goldberg RM, Sargent DJ, Cihon F, Cupit L, Wagner A, Laurent D; CORRECT Study Group.
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial.
The Lancet. 2013;381(9863):303–312.
https://pubmed.ncbi.nlm.nih.gov/23177514/
- Uchino K, Hirano G, Hirahashi M, Isobe T, Shirakawa T, Kusaba H, Baba E, Tsuneyoshi M, Akashi K.
Human Nanog pseudogene8 promotes the proliferation of gastrointestinal cancer cells.
Experimental Cell Research. 2012;318(15):1799–1807.
https://pubmed.ncbi.nlm.nih.gov/22677041/
- Baba E, Fujishima H, Makiyama A, Uchino K, Tanaka R, Esaki T, Kusaba H, Mitsugi K, Nakano S, Akashi K.
Phase 2 study of modified irinotecan and bolus 5-fluorouracil/l-leucovorin in Japanese metastatic colorectal cancer patients.
Advances in Therapy. 2012;29(3):287–296.
https://pubmed.ncbi.nlm.nih.gov/22351434/
- Niiro H, Jabbarzadeh-Tabrizi S, Kikushige Y, Shima T, Noda K, Ota S, Tsuzuki H, Inoue Y, Arinobu Y, Iwasaki H, Shimoda S, Baba E, Tsukamoto H, Horiuchi T, Taniyama T, Akashi K.
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
Blood. 2012;119(10):2263–2273.
https://pubmed.ncbi.nlm.nih.gov/22262777/
- Isobe T, Baba E, Arita S, Komoda M, Tamura S, Shirakawa T, Ariyama H, Takaishi S, Kusaba H, Ueki T, Akashi K.
Human STEAP3 maintains tumor growth under hypoferric condition.
Experimental Cell Research. 2011;317(18):2582–2591.
https://pubmed.ncbi.nlm.nih.gov/21871451/
- Baba E, Esaki T, Ariyama H, Mitsugi K, Morikita T, Fujishima H, Kusaba H, Nakano S, Akashi K.
Phase II study of sequential treatment with S-1 and cisplatin for metastatic gastric cancer.
Cancer Chemotherapy and Pharmacology. 2011;68(3):611–617. https://pubmed.ncbi.nlm.nih.gov/21116623/
- Arita S, Baba E, Shibata Y, Niiro H, Shimoda S, Isobe T, Kusaba H, Nakano S, Harada M.
B cell activation regulates exosomal HLA production.
European Journal of Immunology. 2008;38(5):1423–1434. https://pubmed.ncbi.nlm.nih.gov/18425730/
- Shimoda S, Ishikawa F, Kamihira T, Komori A, Niiro H, Baba E, Harada M, Isse K, Nakanuma Y, Gershwin ME.
Autoreactive T cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory.
Gastroenterology. 2006;131(2):606–618.
https://pubmed.ncbi.nlm.nih.gov/16890612/
- Numata A, Yasuda K, Fukuda T, Baba E, Yamasaki S, Takase K, Miyamoto T, Nagafuji K, Nakano S, Harada M.
Non-myeloablative allogeneic haemopoietic stem cell transplantation for treatment of metastatic invasive thymoma.
The Lancet Oncology. 2005;6(8):626–628.
https://pubmed.ncbi.nlm.nih.gov/16054574/
- Shimoda S, Van de Water J, Nakanuma Y, Ansari AA, Coppel RL, Gershwin ME.
Distinct costimulation dependent and independent autoreactive T cell clones in primary biliary cirrhosis.
Gastroenterology. 2003;125(5):1379–1387.
https://pubmed.ncbi.nlm.nih.gov/14598254/
- Baba E, Takahashi Y, Lichtenfeld J, Tanaka R, Yoshida A, Sugamura K, Yamamoto N, Tanaka Y.
Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand.
Journal of Immunology. 2001;167(2):875–883.
https://pubmed.ncbi.nlm.nih.gov/11441094/
- Davis DM, Mandelboim O, Luque I, Baba E, Boyson J, Strominger JL.
The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells.
Journal of Experimental Medicine. 1999;189(8):1265–1274. https://pubmed.ncbi.nlm.nih.gov/10209043/
- Baba E, Nakamura M, Ohkuma K, Kira J, Tanaka Y, Nakano S, Niho Y.
A peptide-based human T cell leukemia virus type I vaccine containing T and B cell epitopes that induces high titers of neutralizing antibodies.
Journal of Immunology. 1995;154(1):399–412.
https://pubmed.ncbi.nlm.nih.gov/7527817/
- Baba E, Nakamura M, Tanaka Y, Kuroki M, Itoyama Y, Nakano S, Niho Y.
Multiple neutralizing B-cell epitopes of human T-cell leukemia virus type 1 (HTLV-1) identified by human monoclonal antibodies. A basis for the design of an HTLV-1 peptide vaccine.
Journal of Immunology. 1993;151(2):1013–1024.
https://pubmed.ncbi.nlm.nih.gov/7687611/
- Liu S, Ezran C, Wang MFZ, Li Z, Awayan K; Tabula Microcebus Consortium; Long JZ, De Vlaminck I, Wang S, Epelbaum J, Kuo CS, Terrien J, Krasnow MA, Ferrell JE Jr.
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.
Nature Communications. 2024;15(1):2188.
https://pubmed.ncbi.nlm.nih.gov/38467625/
- Zhao J, Wang G, Ming J, Lin Z, Wang Y; Tabula Microcebus Consortium; Wu AR, Yang C.
Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets.
Nature Computational Science. 2022;2(5):317–330.
https://pubmed.ncbi.nlm.nih.gov/38177826/
- Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A; Tabula Muris Consortium; Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake SR, Wyss-Coray T.
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
Nature. 2022;603(7900):309–314.
https://pubmed.ncbi.nlm.nih.gov/35236985/
- Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Morán Losada P, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A, Tan M; Tabula Muris Consortium; Pisco AO, Karkanias J, Neff NF, Keller A, Darmanis S, Quake SR, Wyss-Coray T.
Ageing hallmarks exhibit organ-specific temporal signatures.
Nature. 2020;583(7817):596–602.
https://pubmed.ncbi.nlm.nih.gov/32669715/
- Tabula Muris Consortium.
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse.
Nature. 2020;583(7817):590–595.
https://pubmed.ncbi.nlm.nih.gov/32669714/
- Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.
miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells.
Cancer Research. 2019;79(20):5151–5158.
https://pubmed.ncbi.nlm.nih.gov/31416845/
- Tabula Muris Consortium.
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris.
Nature. 2018;562(7727):367–372.
https://pubmed.ncbi.nlm.nih.gov/30283141/
- Isobe T, Hisamori S, Hogan DJ, Zabala M, Hendrickson DG, Dalerba P, Cai S, Scheeren F, Kuo AH, Sikandar SS, Lam JS, Qian D, Dirbas FM, Somlo G, Lao K, Brown PO, Clarke MF, Shimono Y.
miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway.
eLife. 2014;3: e01977.
https://pubmed.ncbi.nlm.nih.gov/25406066/
- Ezran C, Liu S, Chang S, Ming J, Guethlein LA, Wang MFZ, Dehghannasiri R, Olivieri J, Frank HK, Tarashansky A, Koh W, Jing Q, Botvinnik O, Antony J; Tabula Microcebus Consortium; Pisco AO, Karkanias J, Yang C, Ferrell JE Jr, Boyd SD, Parham P, Long JZ, Wang B, Salzman J, De Vlaminck I, Wu AR, Quake SR, Krasnow MA.
Mouse lemur cell atlas informs primate genes, physiology and disease.
Nature. 2025. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/40739355/
- Tabula Microcebus Consortium, Ezran C, Liu S, Chang S, Ming J, Botvinnik O, Penland L, Tarashansky A, de Morree A, Travaglini KJ, Zhao J, Wang G, Hasegawa K, Sin H, Sit R, Okamoto J, Sinha R, Zhang Y, Karanewsky CJ, Pendleton JL, Morri M, Perret M, Aujard F, Stryer L, Artandi S, Fuller MT, Weissman IL, Rando TA, Ferrell JE Jr, Wang B, De Vlaminck I, Yang C, Casey KM, Albertelli MA, Pisco AO, Karkanias J, Neff N, Wu AR, Quake SR, Krasnow MA.
A molecular cell atlas of mouse lemur, an emerging model primate.
Nature. 2025. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/40739356/
- Ohno M, Takano N, Hidaka K, Sasaki F, Aoki Y, Nohmi T, Tsuzuki T.
Oxidative stress accelerates repeat sequence instability and base substitutions promoting gastrointestinal driver mutations in MSH2 deficient mice.
Genes and Environ 47, 19 (2025).
https://pubmed.ncbi.nlm.nih.gov/41131588/
- Nakajima H, Ohno M, Uno K, Endo S, Suzuki M, Toki H, Saito T.
Effects of generational low dose-rate (137)Cs internal exposure in descendant mice.
Int J Radiat Biol. 2024 Sep;100(11):1-19. doi: 10.1080/09553002.2024.2400521.
https://pubmed.ncbi.nlm.nih.gov/39302823/
- Ohno M, Takano N, Hidaka K, Sasaki F, Yamauchi K, Aoki Y, Nohmi T, Nakabeppu Y, Nakatsu Y, Tsuzuki T.
Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice.
Genome Res. 2024 Feb 7;34(1):47-56. doi: 10.1101/gr.278326.123.
https://pubmed.ncbi.nlm.nih.gov/38290979/
- 大野 みずき ,中津 可道 ,續 輝久
酸化DNA損傷と修復機構.
生体の科学. 2022 Apr;73(2):99-104.
https://webview.isho.jp/journal/detail/abs/10.11477/mf.2425201477
- Oka S, Tsuzuki T, Hidaka M, Ohno M, Nakatsu Y, Sekiguchi M.
Endogenous ROS suppresses endoderm differentiation via FOXC1.
Cell Death Discov 8(1), 150 (2022).
https://pubmed.ncbi.nlm.nih.gov/35365611/
- Aoki Y, Ohno M, Matsumoto M. et al.
Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice.
Genes and Environ 43, 27 (2021).
https://doi.org/10.1186/s41021-021-00196-0
https://pubmed.ncbi.nlm.nih.gov/34225823/
- Aoki Y, Taniguchi Y, Matsumoto M, Matsumoto M, Ohno M, Masumura K, Sasaki S, Tsuzuki T, Yamamoto M, Nohmi T.
Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate.
Mutat Res Genet Toxicol Environ Mutagen. 2020 Feb-Mar;850-851:503136.
doi: 10.1016/j.mrgentox.2020.503136.
https://pubmed.ncbi.nlm.nih.gov/32247553/
- Ohno M.
Spontaneous de novo germline mutations in humans and mice.
Genes Genet Syst. 2019 Apr 9;94(1):13-22.
doi: 10.1266/ggs.18-00015.
https://pubmed.ncbi.nlm.nih.gov/30381610/
- Ohno M.
Toward understanding de novo germline mutations in mammals.
Genes Genet Syst. 2019 Jan;94(1):1.
https://doi.org/10.1266/ggs.94.1
https://pubmed.ncbi.nlm.nih.gov/30971646/
- Uchimura A, Higuchi M, Minakuchi Y, Ohno M, Toyoda A, Fujiyama A, Miura I, Wakana S, Nishino J, Yagi T.
Germline mutation rates and long-term phenotypic effects of mutation accumulation in wild-type and mutator mice.
Genome Res 25(8), 1125–1134 (2015).
https://pubmed.ncbi.nlm.nih.gov/26129709/
- Ohnishi YH, Ohnishi YN, Nakamura T, Ohno M, Kennedy PJ, Ohkawa Y, Nishi A, Neve R, Tsuzuki T, Nestler EJ.
PSMC5 regulates cocaine action in nucleus accumbens.
PLoS One (2015 Jul).
https://pubmed.ncbi.nlm.nih.gov/26110846/
- Ohno M, Sakumi K, Fukumura R, Furuichi M, Iwasaki Y, Hokama M, Ikemura T, Tsuzuki T, Gondo Y, Nakabeppu Y.
8-oxoguanine causes spontaneous de novo germline mutations in mice.
Sci Rep 4, 4689 (2014).
https://doi.org/10.1038/srep04689
https://pubmed.ncbi.nlm.nih.gov/24732879/
- Piao J, Nakatsu Y, Ohno M, Taguchi K, Tsuzuki T.
Mismatch repair deficient mice show susceptibility to oxidative stress-induced intestinal carcinogenesis.
Int J Biol Sci. 2013 Dec 19;10(1):73-9.
doi: 10.7150/ijbs.5750.
https://pubmed.ncbi.nlm.nih.gov/24391453/
- Tsuji H, Ishii-Ohba H, Shiomi T, Shiomi N, Katsube T, Mori M, Nenoi M, Ohno M, Yoshimura D, Oka S, Nakabeppu Y, Tatsumi K, Muto M, Sado T.
Nature of nontargeted radiation effects observed during fractionated irradiation-induced thymic lymphomagenesis in mice.
J Radiat Res 54(3), 453–466 (2013).
https://pubmed.ncbi.nlm.nih.gov/23297316/
- Abolhassani N, Iyama T, Tsuchimoto D, Sakumi K, Ohno M, Behmanesh M, Nakabeppu Y.
NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.
Nucleic Acids Res (2010 May).
https://pubmed.ncbi.nlm.nih.gov/20081199/
- Ohno M.
The influence of oxidized DNA on mammalian genome.
Fukuoka Acta Medica. 2010 Apr.
https://pubmed.ncbi.nlm.nih.gov/20715562/
- Oka S, Ohno M, Nakabeppu Y.
Construction of mitochondrial DNA repair-deficient cell line.
Methods Mol Biol (2009 Oct).
https://pubmed.ncbi.nlm.nih.gov/19513679/
- Ohno M, Oka S, Nakabeppu Y.
Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.
Methods Mol Biol (2009 Oct).
https://pubmed.ncbi.nlm.nih.gov/19513676/
- Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M.
Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease.
PLoS One (2009 Sep).
https://pubmed.ncbi.nlm.nih.gov/19789628/
- Ichikawa J, Tsuchimoto D, Oka S, Ohno M, Furuichi M, Sakumi K, Nakabeppu Y.
Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.
DNA Repair (2008 Mar).
https://pubmed.ncbi.nlm.nih.gov/18155646/
- Oka S, Ohno M, Tsuchimoto D, Sakumi K, Furuichi M, Nakabeppu Y.
Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.
EMBO J 27(2), 421–432 (2008).
https://pubmed.ncbi.nlm.nih.gov/18188152/
- Dan Y, Ohta Y, Tsuchimoto D, Ohno M, Ide Y, Sami M, Kanda T, Sakumi K, Nakabeppu Y.
Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.
DNA Repair (2008 Sep).
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